| September 14, 2021 | Fargo South High School @ Fargo North High School | Fargo North High School | 3-0 |
| September 14, 2021 | Shanley High School @ Fargo Davies High School | Davies High School | 3-0 |
| September 14, 2021 | Grand Forks Central High School @ Grand Forks Red River | Grand Forks Red River | 3-1 |
| September 14, 2021 | West Fargo High School @ Devils Lake Firebirds | Devils Lake High School | 3-0 |
| September 14, 2021 | Valley City High School @ West Fargo Sheyenne High School |